Journal article
Successful immunization of naturally reared pigs against porcine cysticercosis with a recombinant oncosphere antigen vaccine
CM Jayashi, CT Kyngdon, CG Gauci, AE Gonzalez, MW Lightowlers
Veterinary Parasitology | Published : 2012
Abstract
Taenia solium causes cysticercosis in pigs and taeniasis and neurocysticercosis in humans. Oncosphere antigens have proven to be effective as vaccines to protect pigs against an experimental infection with T. solium. A pair-matched vaccination trial field, using a combination of two recombinant antigens, TSOL16 and TSOL18, was undertaken in rural villages of Peru to evaluate the efficacy of this vaccine under natural conditions. Pairs of pigs (n=137) comprising one vaccinated and one control animal, were allocated to local villagers. Animals received two vaccinations with 200. μg of each of TSOL16 and TSOL18, plus 5. mg Quil-A. Necropsies were performed 7 months after the animals were distri..
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Awarded by National Health and Medical Research Council
Funding Acknowledgements
The authors thank the Cysticercosis Working Group in Tumbes for their support during the animal necropsies. The Laboratory of Preventive Veterinary Medicine, Faculty of Veterinary Medicine, of the Universidad Nacional Mayor de San Marcos, for their technical support and assistance in laboratory and field work duties. We thank all families in Morropon for their collaboration and enthusiasm through the study. Funding from the Australian National Health and Medical Research Council (grant number 350279) (ML), and The Wellcome Trust, UK (ML, AG) are acknowledged.